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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Neuroimage. 2008 Nov 5;44(4):1247–1258. doi: 10.1016/j.neuroimage.2008.10.030

Figure 1.

Figure 1

WM parcellation method. The WM parcellation method is an extension of a previously described cortical reconstruction (left panel, top), segmentation (left panel, middle) and parcellation procedure (left panel, bottom) that utilized spherical spatial normalization (Fischl et al., 1999b) to label gyral and sulcal areas throughout the brain (Desikan et al., 2006; Fischl et al., 2004). Cortical parcellations were subsequently used to assign a label to the underlying white matter by the construction of a Voronoi diagram in the WM voxels of the MR volume based on distance to the nearest cortical parcellation label (right panel, top and middle). Each Voronoi polygon then inherited the label of the parcellation unit, yielding a complete labeling of the cerebral WM. Measures were corrected for head size with an atlas-based scaling procedure (Buckner et al., 2004) for quantitative analysis.