Table 4.

Reduction in WM volume with AD: ANCOVA for each region covarying for age.

WM Region	F-Value (LH/RH)	P-Value (LH/RH)	% Difference OLD > AD (LH/RH)
Banks STS	2.62/8.46	0.108/0.004	4.06/7.68
Caudal Anterior Cingulate	0.74/0.43	0.391/0.512	2.53/1.75
Caudal Middle Frontal	7.35/2.89	0.007/0.091	2.36/4.13
Cuneus	8.24/3.03	0.004¥/0.084¥	11.07/6.01
Entorhinal	8.58*/24.47	0.004*¥/<0.001¥	21.34/25.86
Fusiform	4.29/8.20	0.040¥/0.005¥	5.62/6.26
Inferior Parietal	16.79/11.681*	<0.001¥/<0.001*¥	8.25/8.82
Inferior Temporal	15.23/8.52	<0.001¥/0.004¥	10.75/7.17
Isthmus Cingulate	13.66/9.66	<0.001¥/0.002¥	7.85/7.39
Lateral Occipital	6.10/2.90	0.015¥/0.090	8.04/4.79
Lateral Orbitofrontal	8.89*/5.26	0.003*¥/0.023¥	4.29/3.96
Lingual	14.63/9.82	<0.001¥/0.002¥	11.92/9.37
Medial Orbitofrontal	0.55/6.23*	0.461/0.014*	2.36/4.26
Middle Temporal	16.02/9.812*	<0.001¥/0.002*¥	10.15/7.92
Parahippocampal	40.09/48.397	<0.001¥/<0.001¥	16.36/17.14
Paracentral	0.22/0.28	0.641/0.595	1.45/−0.89
Pars Opercularis	0.00/4.767	0.955/0.031¥	0.24/5.77
Pars Orbitalis	1.92/0.71	0.168/0.401	4.28/2.35
Pars Triangularis	0.19/0.05	0.667/0.820	1.21/0.95
Pericalcarine	10.23/9.36	0.002¥/0.003¥	12.12/11.13
Postcentral	5.31/2.89	0.023/0.091	4.33/3.32
Posterior Cingulate	3.91/0.14	0.050/0.708	3.88/−0.42
Precentral	1.22/0.65	0.272/0.422	1.91/1.24
Precuneus	18.61/10.10	<0.001¥/0.002¥	8.41/5.89
Rostral Anterior Cingulate	1.20/0.10	0.275/0.749	2.57/−1.24
Rostral Middle Frontal	23.80/5.34	<0.001¥/0.022	9.57/4.75
Superior Frontal	9.66/5.55	0.002/0.020	5.74/4.25
Superior Parietal	9.90/6.49	0.002¥/0.012	6.07/5.15
Superior Temporal	1.20/0.634	0.275/0.427	2.23/1.38
Supramarginal	16.27/2.41	<0.001¥/0.123	6.83/2.62
Frontal Pole	0.451/0.04	0.503/0.839	2.49/0.86
Temporal Pole	11.74/7.59	0.001¥/0.007¥	15.47/11.10
Transverse Temporal	0.05/0.07	0.831/0.786	0.61/0.26

^*Regions showing a significant group by age interaction

^¥Unpaired comparison of OLD to CDR .5 AD alone p < 0.05