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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: Dev Biol. 2009 Mar 3;329(2):242–257. doi: 10.1016/j.ydbio.2009.02.024

Figure 11. Interaction of IHH and FGF signaling.

Figure 11

Matched wt and nm E8 tibias were cultured for 2 days with (+) or without (−)10μM cyclopamine. A. Total tibial length at the end of the culture time was measured using the ImageJ program, and data were evaluated for statistical significance using the Student's t-test for correlated samples. * p<0.001. B. Expression of FGFR3, IHH, and COL10A1 detected by in situ hybridizations using DIG-labeled probes in serial 40 μm sections from wt and nm cultured tibia explants with or without cyclopamine treatment.