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. Author manuscript; available in PMC: 2010 Aug 13.
Published in final edited form as: J Med Chem. 2009 Aug 13;52(15):4604–4612. doi: 10.1021/jm9002999

Table 1.

EC50 values of Luc induction in HeLa cells by selected Py-Im polyamides dexamethasone conjugates and dexamethasone derivatives.

Compound EC50 (µM)
ImPy-Et-Sdex (23) 0.75 ± 0.13
ImPy2-Et-Sdex (22) 1.2 ± 0.28
Ac-Et-Sdex (15) 0.29 ± 0.061
Ac-Da-Sdex (28) 0.80 ± 0.13
IBA-Sdex (5) 0.35 ± 0.02a
ImPy-Et-Oxdex (27) 4.2 ± 0.75
ImPy2-Et-Oxdex (26) 8.1 ± 1.7
Oxdex-CONH2 (4) 35 ± 3b
a

Reference 20.

b

Reference 15.