Table 2.
Compound | IC50 (nM) | Compound | IC50 (nM) |
---|---|---|---|
ImPy7γ̃βDa-Sdex (6) | 14 ± 0.87 | ImPy7γ-Et-Sdex (16) | 27 ± 2.1 |
ImPy6γ̃βDa-Sdex (7) | 20 ± 1.1 | ImPy6γ-Et-Sdex (17) | 21 ± 1.7 |
ImPy5γ̃βDa-Sdex (8) | 22 ± 2.9 | ImPy5γ-Et-Sdex (18) | 21 ± 2.3 |
ImPy4γ̃βDa-Sdex (9) | 16 ± 1.1 | ImPy4γ-Et-Sdex (19) | 23 ± 2.6 |
ImPy4-βDa-Sdex (10) | 16 ± 2.0 | ImPy4-Et-Sdex (20) | 34 ± 2.5 |
ImPy3-βDa-Sdex (11) | 20 ± 1.1 | ImPy3-Et-Sdex (21) | 26 ± 1.8 |
ImPy2-βDa-Sdex (12) | 12 ± 0.82 | ImPy2-Et-Sdex (22) | 14 ± 0.80 |
ImPy-βDa-Sdex (13) | 8.5 ±0.43 | ImPy-Et-Sdex (23) | 5.7 ± 0.30 |
ImPy7γ-Et-Oxdex (24) | 840 ± 130 | Ac-Et-Sdex (15) | 9.8 ± 0.88 |
ImPy3-Et-Oxdex (25) | 550 ± 57 | Ac-Da-Sdex (28) | 8.3 ± 0.61 |
Impy2-Et-Oxdex (26) | 480 ± 69 | Ac-βDa-Sdex (14) | 9.3 ± 0.48 |
ImPy-Et-Oxdex (27) | 460 ± 42 | dexamethasonea (1) | 5 ± 1 |
Oxdex-CONH2 c (4) | 600 ± 100 | IBA-Sdexb (5) | 15 ± 1.5 |