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. Author manuscript; available in PMC: 2010 Jan 25.
Published in final edited form as: J Immunol. 2008 May 1;180(9):6392–6401. doi: 10.4049/jimmunol.180.9.6392

FIGURE 8.

FIGURE 8

RISER augments Ab-induced NK cell-mediated ADCC. NK cells from five healthy donors (n = 5) were incubated with 51Cr-labeled autologous EBV-transformed B cells at a 10:1 E:T ratio in the presence of rituximab (A) or mutant anti-CD19 Ab (Xencor) (B) or in the absence (□) or presence (■) of NK cell RISER Abs combination binding NKG2A, CD94, KIR3DL1, KIR2DL1, KIR2DL3, KIR2DL2, and KIR2DS2. Cytotoxicity was calculated using a 4-h 51Cr release assay. All Abs were used at 1 μg/ml concentration. Results shown are mean ± SD of one representative experiment of at least three independent experiments.