Figure 2.
Histopathology of UIP (higher power). A hallmark of UIP is the heterogeneity, represented by dense, acellular bundles of collagen with smooth muscle metaplasia (arrow) in close approximation to the fibroblastic focus (FF), a dense collection of fibroblasts and myofibroblasts. Cuboidal epithelial cells lining distorted airspaces (which may be undergoing apoptosis) are seen overlying the fibroblastic focus