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. Author manuscript; available in PMC: 2010 Apr 16.
Published in final edited form as: Neuron. 2009 Apr 16;62(1):72–83. doi: 10.1016/j.neuron.2009.02.020

Figure 5. Cys257 is not required for downstream signaling by the p75NTR/NgR/Lingo-1 complex in response to MAG.

Figure 5

(A) Binding of RhoGDI to wild type and C257A p75NTR in COS-7 cells co-transfected with NgR and Lingo-1 and stimulated with MAG-Fc.

(B) RhoA activity in COS-7 cells transfected with wild type and mutant p75NTR in the presence of NgR and Lingo-1 after stimulation with MAG-Fc for 30 min. Results are expressed as mean ± SD relative to wild type without MAG treatment. *, p<0.05 vs. control, n=3.