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. Author manuscript; available in PMC: 2011 Jan 19.
Published in final edited form as: Circulation. 2009 Dec 28;121(2):276–292. doi: 10.1161/CIRCULATIONAHA.109.895771

Figure 2.

Figure 2

Figure 2

Figure 2

Cell cycle regulators and oxidative stress. A–D, DOXO affects the expression of cyclins, cyclin-dependent kinases, Rb (A) and cyclin-dependent kinase inhibitors (B), increases DNA damage (C: 8-OH-dG, red) and decreases the activity of SOD and catalase (D) in CPCs (C: c-kit, green).