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. Author manuscript; available in PMC: 2011 Jan 19.
Published in final edited form as: Circulation. 2009 Dec 28;121(2):276–292. doi: 10.1161/CIRCULATIONAHA.109.895771

Figure 6.

Figure 6

CPC death and growth. A–C, DOXO administration enhances apoptosis (A: TdT, white), senescence (B: p16INK4a, yellow) and decreases proliferation (C: Ki67, yellow) of CPCs (c-kit, green) in vivo at 3 and 6 weeks after the first injection of anthracycline. D, Oxidative damage (8-OH-dG, magenta) in CPCs increases after DOXO treatment in vivo. E, Number of functionally competent CPCs in control and DOXO-treated rats at 3 and 6 weeks. *,** P< 0.05 vs. C and 3 wks, respectively.