FIG. 5.

Effect of H-1152 on the intraocular pressure (IOP) of rats. H-1152 (10 mM) was administered topically to rat eyes. The contralateral eyes were treated with phosphate-buffered saline. The results are presented as the mean ± standard error of the mean (n = 10 for each group). IOP decreased significantly 0.5–6 h after H-1152 treatment (A). (B) Average IOP for H-1152- and contralateral vehicle-treated eyes corrected for baseline. Differences were significantly different from 0.0 by the two-tailed paired Student t-test.