Table 3.
Risk estimate for BPDE-induced 3p deletions with subjects grouped according to the quartile distribution in the controls
| No. (%) |
Adjusted OR (95% CI)* | p for trend | ||
|---|---|---|---|---|
| Cases | Controls | |||
| 3p25.2 deletion | ||||
| 1st quartile | 16 (11.5) | 18 (17.5) | Reference | |
| 2nd quartile | 28 (20.1) | 31 (30.1) | 1.15 (0.47–2.78) | |
| 3rd quartile | 25 (25.2) | 27 (26.2) | 1.63 (0.68–3.90) | |
| 4th quartile | 60 (43.2) | 27 (26.2) | 2.80 (1.20–6.57) | 0.004 |
| 3p21.3 deletion | ||||
| 1st quartile | 18 (12.2) | 24 (22.2) | Reference | |
| 2nd quartile | 26 (17.6) | 26 (24.1) | 1.42 (0.61–3.30) | |
| 3rd quartile | 43 (29.0) | 27 (25.0) | 2.48 (1.11–5.57) | |
| 4th quartile | 61 (41.2) | 31 (28.7) | 3.04 (1.39–6.64) | 0.002 |
| 3p14.2 deletion | ||||
| 1st quartile | 7 (5.2) | 24 (22.6) | Reference | |
| 2nd quartile | 36 (26.7) | 24 (22.6) | 5.04 (1.82–13.9) | |
| 3rd quartile | 40 (29.6) | 28 (26.4) | 5.09 (1.91–13.6) | |
| 4th quartile | 52 (38.5) | 30 (28.4) | 5.95 (2.21–16.0) | 0.003 |
| 3p12.2 deletion | ||||
| 1st quartile | 21 (15.3) | 20 (18.6) | Reference | |
| 2nd quartile | 20 (14.6) | 30 (28.0) | 0.64 (0.27–1.49) | |
| 3rd quartile | 44 (32.1) | 30 (28.0) | 1.31 (0.59–2.90) | |
| 4th quartile | 52 (38.0) | 27 (25.2) | 1.78 (0.81–3.89) | 0.028 |
*
Odds ratio (OR) adjusted for age (as a continuous variable), gender, ethnicity, and smoking status; data are means and 95% confidence intervals (CI)
Not all patients and controls had completed analysis for deletions at each locus