Table 2.
Comparison between demographic and biochemical variables between White HIV-infected patients without treatment and HIV-infected patients treated with efavirenz (EFV)
| HIV–infected patients | |||
|---|---|---|---|
| Parameter | Untreated | EFV | P-value |
| n | 18 | 18 | |
| Male | 11 | 15 | |
| Age (years) | 38 (32, 43) | 44 (37, 51) | NS |
| Body mass index (kg m−2) | 25 (22, 28) | 23 (22, 25) | NS |
| GGT (U l−1) | 32 (13, 50) | 49 (20, 77) | NS |
| AP (U l−1) | 65 (52, 78) | 87 (69, 104) | NS |
| AST (U l−1) | 24 (15, 33) | 20 (17, 23) | NS |
| ALT (U l−1) | 38 (20, 55) | 29 (20, 39) | NS |
| CD4 cell count (cells mm−3) | 492 (397, 588) | 594 (445, 742) | NS |
| TC (mg dl−1) | 179 (159, 200) | 187 (173, 200) | NS |
| LDL-c (mg dl−1) | 118 (98, 138) | 115 (99, 131) | NS |
| HDL-c (mg dl−1) | 48 (42, 54) | 46 (39, 52) | NS |
| TG (mg dl−1) | 89 (68, 109) | 126 (90, 162) | NS |
| TC : HDL-c ratio | 3.86 (3.30, 4.14) | 4.35 (3.71, 4.98) | NS |
| PON-1 activity (U l−1) | 58.80 (51.36, 66.23) | 77.35 (65.66, 89.04) | <0.05 |
| PON-1 activity : HDL-c ratio | 1.30 (1.11, 1.49) | 1.88 (1.49, 2.28) | <0.01 |
Data are expressed has mean (95% CI). NS, nonsignificant (P > 0.05); n, number of patients; GGT, γ-glutamyltranspeptidase; reference range (RR) < 36 U l−1; AP, alkaline phosphatase; RR 35–104 U l−1; AST, aspartate aminotransferase; RR < 31 U l−1; ALT, alanine aminotransferase; RR < 31 U l−1. To convert total cholesterol (TC) high-density (HDL-c) and low-density (LDL-c) lipoprotein cholesterol to mmol l−1 multiply by 0.0259. For triglycerides (TG), the conversion value is 0.0113. RR, TC < 200 mg dl−1; TG < 150 mg dl−1, HDL-c > 40 mg dl−1, LDL-c < 150 mg dl−1.