Table 3.

Estimated ratios of pharmacokinetics of liraglutide in subjects with renal impairment vs. healthy subjects

	Mild: healthy	Moderate: healthy	Severe: healthy	End stage: healthy
n	6	7	5	6
AUC
Estimate (90% CI)	0.67 (0.54, 0.85)	0.86 (0.70, 1.07)	0.73 (0.57, 0.94)	0.74 (0.56, 0.97)
Cmax
Estimate (90% CI)	0.75 (0.57, 0.98)	0.96 (0.74, 1.23)	0.77 (0.57, 1.03)	0.92 (0.67, 1.27)
tmax (h)
Estimate (90% CI)	−2.00 (−6.00, 2.00)	0.00 (−4.50, 2.50)	−1.50 (−7.00, 0.50)	–2.50 (−8.50, −1.00)
t1/2 (h)
Estimate (90% CI)	0.79 (0.68, 0.91)	0.79 (0.69, 0.91)	0.79 (0.68, 0.93)	0.71 (0.60, 0.84)
CL/F
Estimate (90% CI)	1.48 (1.18, 1.87)	1.16 (0.93, 1.44)	1.37 (1.07, 1.76)	1.36 (1.04, 1.78)

Estimates are ratio except for t_max, where differences are shown.