Table 1.
Statistical analysis of midazolam pharmacokinetic variables*
| Mean (±SE, n= 13) for treatment conditions: | Dunnett's test | |||||
|---|---|---|---|---|---|---|
| Placebo | ALT-2074 | Ritonavir | Repeated measures anova | ALT-2074 vs. placebo | Ritonavir vs. placebo | |
| Cmax (ng ml−1) | 9.0 (±1.0) | 10.6 (±0.9) | 35.6 (±2.8) | F = 81.8, P < 0.001 | NS | P < 0.05 |
| t1/2 (h) | 2.06 (±0.15) | 2.08 (±0.17) | 18.07 (±2.25) | F = 49.4, P < 0.001 | NS | P < 0.05 |
| Total AUC (ng ml−1 h−1) | 24.65 (±1.93) | 29.87 (±2.62) | 651 (±77) | F = 64.9, P < 0.001 | NS | P < 0.05 |
| Clearance (ml min−1) | 2157 (±142) | 1844 (±167) | 85.9 (±6.9) | F = 92.2, P < 0.001 | NS | P < 0.05 |
| Clearance (ml min−1 kg−1) | 28.84 (±2.84) | 24.15 (±2.38) | 1.13 (±0.11) | F = 64.1, P < 0.001 | NS | P < 0.05 |
*
Analysis of actual values without transformation.