Table 1.

Characteristics of women exposed and unexposed to folic acid antagonists in the first trimester of pregnancy

	Exposure to folic acid antagonists
Variable	Yes, n= 571	No, n= 85 250	P-value
Maternal age (mean ± SD)	28.3 ± 6.5	28.0 ± 6.0	0.266
Ethnic group*
Jews	185 (32.4%)	31,028 (36.4%)	0.053
Bedouins	386 (67.6%)	54,208 (63.6%)
Maternal smoking	12 (2.1%)	2173 (2.5%)	0.587
Maternal diabetes	45 (7.9%)	5658 (6.6%)	0.269
Peripartum fever†	9 (1.7%)	792 (0.9%)	0.111
Mean parity (mean ± SD)	3.6 ± 2.8	3.7 ± 2.7	0.477

^*Data regarding ethnicity were missing in 14 therapeutic pregnancy terminations.

^†Not included pregnancy terminations.