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. 2009 Aug 26;1(3):e00015. doi: 10.1042/AN20090008

Figure 6. smvEC expression of PAI-1 is rapidly induced by ischaemic SCI.

Figure 6

No detectable PAI-1 immunoreactivity was observed in control spinal grey matter (B). As early as 3 h post-ischaemia, robust PAI-1 immunoreactivity is observed in affected smvECs (C and D; arrowheads). This expression level is maintained in smvECs for up to 3 days post-ischaemia (E–H; arrowheads). By 5 days post-ischaemia, PAI-1 immunoreactivity returned to basal levels in perfused spinal microvessels (I and J). Confocal imaging definitively co-localizes PAI-1 to FITC–LEA activated/perfused spinal microvessels in the xz and yz planes (F and H; arrows). Scale bar = 50 μm (A–J).