TABLE 1.
Blood Physiologic Variables, Temperature, Anesthesia, and Number of SDs1
| Animal group (survival) | PH | PaCO2 (torr) | PaO2 (torr) | Hematocrit (%) | Blood pressure (mm Hg) | Temperature (°C) | Halothane (%) | SDs (No.) | Glucose (mMol) |
|---|---|---|---|---|---|---|---|---|---|
| Time studies | |||||||||
| Sham | 7.21 ± 0.05 | 64 ± 4 | 99 ± 12 | 40 ± 2 | 107 ± 7 | 37.3 ± 0.2 | 1.7 ± 0.1 | 0 ± 0* | 3.4 ± 3.3 |
| 0 (1 hour SD) | 7.17 ± 0.02 | 57 ± 4 | 100 ± 8 | 42 ± 2 | 92 ± 14 | 37.5 ± 0.2 | 1.8 ± 0.0 | 12 ± 2* | 6.9 ± 1.4 |
| 0 (3 hour SD) | 7.21 ± 0.05 | 65 ± 4 | 94 ± 10 | 40 ± 4 | 110 ± 10 | 37.7 ± 0.7 | 1.2 ± 0.2 | 27 ± 8 | 3.3 ± 3.3 |
| 3 hour | 7.21 ± 0.01 | 61 ± 4 | 105 ± 6 | 43 ± 4 | 115 ± 15 | 37.7 ± 0.4 | 1.2 ± 0.0 | 28 ± 4 | 6.5 ± 1.8 |
| 6 hour (COX) | 7.24 ± 0.02 | 58 ± 5 | 94 ± 1 | 42 ± 5 | 97 ± 12 | 37.6 ± 0.5 | 1.2 ± 0.3 | 28 ± 6 | 2.4 ± 0.0 |
| 6 hour (LIPOX) | 7.34 ± 0.06 | 56 ± 9 | 104 ± 3 | 40 ± 1 | 110 ± 5 | 37.6 ± 0.1 | 2.0 ± 0.0 | 20 ± 2 | 5.2 ± 0.6 |
| 1 day | 7.20 ± 0.02 | 59 ± 4 | 105 ± 15 | 43 ± 4 | 97 ± 6 | 37.2 ± 0.1 | 1.3 ± 0.1 | 25 ± 12 | 4.5 ± 4.3 |
| 2 day | 7.25 ± 0.05 | 58 ± 4 | 117 ± 23 | 38 ± 8 | 106 ± 17 | 37.4 ± 0.4 | 1.3 ± 0.2 | 29 ± 4 | 4.1 ± 2.8 |
| 3 day | 7.21 ± 0.09 | 61 ± 9 | 102 ± 20 | 41 ± 5 | 112 ± 10 | 37.2 ± 0.2 | 1.3 ± 0.1 | 30 ± 9 | 5.6 ± 0.4 |
| 7 day | 7.21 ± 0.03 | 67 ± 8 | 114 ± 6 | 41 ± 3 | 95 ± 10 | 37.9 ± 0.5 | 1.3 ± 0.3 | 24 ± 2 | 8.2 ± 2.7 |
| 14 day | 7.21 ± 0.02 | 64 ± 5 | 104 ± 17 | 43 ± 0 | 106 ± 12 | 37.4 ± 0.0 | 1.8 ± 0.3 | 24 ± 7 | 6.7 ± 0.0 |
| 21 day (COX) | 7.20 ± 0.00 | 62 ± 3 | 93 ± 6 | 41 ± 1 | 106 ± 9 | 37.3 ± 0.5 | 1.8 ± 0.3 | 24 ± 4 | 7.1 ± 0.7 |
| 21 day (LIPOX) | 7.34 ± 0.02 | 53 ± 4 | 98 ± 12 | 40 ± 0 | 107 ± 3 | 37.1 ± 0.2 | 1.8 ± 0.1 | 21 ± 1 | 5.0 ± 0.2 |
| 28 day | 7.23 ± 0.07 | 68 ± 10 | 97 ± 4 | 44 ± 1 | 115 ± 13 | 37.1 ± 0.1 | 1.5 ± 0.3 | 17 ± 1 | 5.8 ± 1.3 |
| Hippo | 7.25 ± 0.02 | 68 ± 3 | 96 ± 7 | 45 ± 2 | 118 ± 6 | 37.0 ± 0.2 | 1.6 ± 0.3 | 21 ± 1 | 4.8 ± 0.3 |
| Drug studies | |||||||||
| Dex | 7.30 ± 0.05 | 58 ± 3 | 104 ± 4 | 38 ± 0 | 114 ± 9 | 37.4 ± 0.3 | 1.5 ± 0.0 | 30 ± 6 | 5.3 ± 0.0 |
| Mep | 7.29 ± 0.03 | 57 ± 4 | 105 ± 12 | 42 ± 4 | 118 ± 28 | 37.2 ± 0.3 | 1.5 ± 0.4 | 25 ± 7 | 4.0 ± 0.3 |
| Indo | 7.22 ± 0.01 | 69 ± 6* | 103 ± 2 | 39 ± 1 | 125 ± 25 | 37.2 ± 0.1 | 1.4 ± 0.1 | 27 ± 5 | 5.1 ± 1.7 |
| Ndga | 7.29 ± 0.06 | 58 ± 9 | 105 ± 17 | 41 ± 4 | 114 ± 10 | 37.4 ± 0.4 | 1.4 ± 0.4 | 18 ± 5 | 5.3 ± 1.0 |
| Eph | 7.31 ± 0.01 | 59 ± 5 | 103 ± 14 | 42 ± 1 | 150 ± 13* | 37.1 ± 0.6 | 1.4 ± 0.1 | 19 ± 1 | 6.4 ± 0.8 |
| Snp/Ep | 7.25 ± 0.04 | 54 ± 5 | 109 ± 7 | 43 ± 1 | 99 ± 34 | 37.3 ± 0.2 | 1.6 ± 0.2 | 14 ± 3* | 11.0 ± 1.1* |
| Lnam | 7.20 ± 0.01 | 65 ± 2* | 101 ± 10 | 41 ± 1 | 123 ± 10 | 37.4 ± 0.2 | 1.4 ± 0.1 | 20 ± 5 | 5.6 ± 0.3 |
1
All values are means ± standard deviation.
*
Indicates significantly different from other groups according to ANOVA and post-hoc Tukey. All groups contain three to five animals.