Table 1.
Clinical remission and response for patients with depression affected by specific domains of cognition
| Cognitive Status | Percent remission of depression (HDRS<10), (n) | Percent response (≥50 change in HDRS), n is same as for remission |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 month | 8 month | 12 month | 4 month | 8 month | 12 month | ||||||||
| Intervention | Usual Care |
Intervention | Usual Care |
Intervention | Usual Care |
Intervention | Usual Care |
Intervention | Usual Care |
Intervention | Usual Care |
||
| MMSE | MMSE < 24 | 33(18) | 33(21) | 36(14) | 40(20) | 50(14) | 50(18) | 44 | 33 | 29 | 50 | 43 | 22 |
| MMSE ≥ 24 | 49(235) | 35(214) | 50(222) | 44(194) | 55(203) | 53(170) | 43 | 29 | 47 | 34 | 53 | 44 | |
|
Verbal memory DRS memory, immediate recall |
Lowest quartile |
52(54) | 31(49) | 46(48) | 46(41) | 55(47) | 58(31) | 48 | 24 | 44 | 37 | 53 | 42 |
| Highest three quartiles |
52(132) | 37(145) | 52(126) | 42(135) | 55(111) | 51(121) | 44 | 31 | 48 | 35 | 53 | 41 | |
|
Verbal memory DRS memory, delayed recall |
Lowest quartile |
54(48) | 32(44) | 44(41) | 46(37) | 54(37) | 48(33) | 50 | 25 | 37 | 35 | 46 | 36 |
| Highest three quartiles |
51(137) | 36(148) | 52(132) | 43(137) | 55(120) | 53(118) | 43 | 30 | 50 | 36 | 55 | 42 | |
|
Attention Weschler digit span |
Lowest quartile |
41(37) | 26(47) | 47(34) | 34(38) | 45(31) | 55(29) | 43 | 21 | 41 | 34 | 52 | 45 |
| Highest three quartiles |
56(143) | 39(147) | 52(134) | 45(138) | 57(122) | 52(123) | 48 | 33 | 49 | 36 | 52 | 40 | |
|
Response Inhibition Stroop Color-Word |
Lowest quartile |
60(47) | 26(38) | 50(46) | 44(32) | 56(43) | 48(27) | 60 | 21 | 43 | 41 | 47 | 26 |
| Highest three quartiles |
45(134) | 35(135) | 50(119) | 42(125) | 52(112) | 55(109) | 40 | 29 | 48 | 32 | 51 | 47 | |
Notes: Data gathered from the PROSPECT study. HDRS = Hamilton Depression Rating Scale; MMSE = Mini-Mental State Examination; DRS = Mattis Dementia Rating Scale