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. 2009 Nov 5;38(2):428–440. doi: 10.1093/nar/gkp844

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 1. — (A) Interconversion of the cis-(5R,6S) and trans-(5R,6R) Tg lesions. When the 5R-Tg isomer is paired opposite dA in this 5′-GTgG-3′ sequence a 7:3 cis-(5R,6S): trans-(5R,6R) mixture is present at equilibrium, in slow exchange on the NMR timescale (12). (B) Oligodeoxynucleotide duplex used for NMR studies, indicating the numbering of the nucleotides. X⁶ is the cis-(5R,6S) Tg lesion.