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. 2009 Nov 11;38(2):477–487. doi: 10.1093/nar/gkp976

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — SMC1 depletion impairs the repair of DSBs in G2-phase cells. (A) γH2AX and CENP-F staining in SMC1-depleted cells 2 h after 1 Gy X-irradiation. (B) Time course for the loss of 1 Gy X-ray-induced γH2AX foci in G1- (CENP-F negative) and late S/G2-phase cells (CENP-F strongly positive). (C) 53BP1, Cyclin A and BrdU staining in SMC1-depleted cells 2 h after 1 Gy X-irradiation. (D) Time course for the loss of 1 Gy X-ray-induced 53BP1 foci in G1 (BrdU-negative cyclin A-negative) and G2-phase cells (BrdU-negative cyclin A positive). Error bars are standard errors of the mean from two to three experiments.