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. 2009 Nov 11;38(2):382–390. doi: 10.1093/nar/gkp991

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — The effect of RNAi targeting HRPT2 or Paf1 on cellular cyclin D1 levels. (A) Parafibromin represses cyclin D1 promoter activity. The 293T cells were transfected with Flag-parafibromin along with a cyclin D1 promoter (–1735) reporter. The means ± SD of duplicate determinations from three separate experiments are shown. The expression level of transfected Flag-parafibromin was shown at the bottom. (B) Increased cyclin D1 levels following parafibromin or Paf1 knockdown. Immunoblotting of HeLa cells transfected with siRNAs against HRPT2 (parafibromin) or control siRNA (left panel) and stably expressed scrambled or Paf1 shRNA (right panel).