Fig. 1.

CD36 mediates cell-specific responses. (A) In endothelial cells, CD36 inhibits angiogenesis induced by growth factors, such as fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF), and promotes apoptosis. (B) In macrophages and monocytes, CD36 promotes inflammatory responses and phagocytosis. CD36 may interact with other receptors, such as integrins, TLRs, or tetraspanins, to mediate some of the responses. (C) In platelets, CD36 promotes activation, aggregation, and secretion. (D) In monocytes and macrophages, CD36 promotes the uptake of bioactive lipids, leading to activation of PPARγ transcriptional pathways. (E) In sensory cells, CD36 contributes to cellular responses in the mouth and gut to dietary fats in mammals (right) and to pheromone responses in Drosophila (left).