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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Neuropsychopharmacology. 2009 Jun 10;34(10):2305–2322. doi: 10.1038/npp.2009.58

Figure 5.

Figure 5

GLS1 hets show reduced contextual fear conditioning, but are not impaired in other memory tasks. (a) During fear conditioning on day 1, both GLS1 hets and WT littermates showed increased freezing with repeated CS-US pairings (a1) On day 2, both genotypes froze significantly more during the tone period than during the pre-tone period (a2) However, on day 3, GLS1 hets froze significantly less in the context test. *WT > GLS1 hets, p < 0.05. (b) In the Morris Water Maze task during hidden platform (PF) training, both genotypes displayed improved performance (ie, decreased latencies) over successive training days (b1). On day 8, immediately after the last session of hidden PF training (b2), and on day 15, 1 week post-hidden PF training (b3), both genotypes spent significantly more time in the target quadrant (1). (c) In the Object Recognition Test, both GLS1 hets and WT littermates spent more time exploring the novel object than the familiar one; there were no genotypic differences.