Figure 8.
GLS1 hets display clozapine-like potentiation of latent inhibition. (a) Mean percent freezing of pre-exposed (PE) and non-pre-exposed (NPE) saline- and clozapine-treated WT and GLS1 het mice during the pre-tone period on the test day. Similar low freezing levels were observed in all groups. (b) Freezing ratios during the tone test. Latent inhibition, that is, a lower suppression ratio in PE as compared with NPE mice, was observed in clozapine-treated WT mice and in saline- and clozapine-treated GLS1 hets, but not in saline-treated WT mice. NPE > PE, *p < 0.05, **p < 0.01.