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. 2010 Jan 26;8(1):e1000293. doi: 10.1371/journal.pbio.1000293

Genome-wide association studies have implicated hundreds of common variants of miniscule effect in diverse traits but a new study suggests that rare variants of much stronger effect may underlie some of these associations. Thus, large-scale sequencing may uncover more definitive leads about disease pathophysiology than the study of common variation has afforded.

Genome-wide association studies have implicated hundreds of common variants of miniscule effect in diverse traits but a new study suggests that rare variants of much stronger effect may underlie some of these associations. Thus, large-scale sequencing may uncover more definitive leads about disease pathophysiology than the study of common variation has afforded.