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. 2010 Jan 26;5(1):e8891. doi: 10.1371/journal.pone.0008891

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Hu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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FTOC from embryonic day 16 of WT and Itk null mice incubated in vitro for the indicated days, gated on TCR^hi and analyzed for CD4 and CD8 (data representative of 3–4 mice). (B) Active Itk kinase activity is required for T cell development. Thymocytes from WT, Itk^−/−, Tg(Lck-ItkΔKin)Itk^−/− and Tg(CD2-Itk_tg)Itk^−/− mice were gated first on the TCR^hi and analyzed for expression of CD4 and CD8.