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. 2010 Jan 26;5(1):e8891. doi: 10.1371/journal.pone.0008891

Figure 4. The absence of Itk affects the development of CD4+ T cells in DO11.10 transgenic mice.

Figure 4

(A) Total thymocytes (left panels) or the transgenic TCR+ (KJ-11+) population from DO11.10 and DO11.10/Itk−/− mice analyzed for expression of CD4 and CD8 (right panel). (B) The number of thymocytes (total, left) or transgene TCRhi thymocytes (right) in WT and Itk−/− mice. *p<0.05, n = 3–5 mice. (C) Total lymphocytes (left panel) or the transgenic TCR+ population (right panel) from cervical lymph nodes of DO11.10 and DO11.10/Itk−/− mice analyzed for expression of CD4 and CD8. (D) The number of total lymphocytes (left) or the transgene TCR+ T cells from cervical lymph nodes (n = 3–5, *p<0.05).