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. 1998 Dec 22;95(26):15730–15734. doi: 10.1073/pnas.95.26.15730

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Copyright © 1998, The National Academy of Sciences

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GLYT1 antagonism can alter glycine concentration proximal to the NMDAR. (A) Glycine (1 μM) in the bath caused no change on the amplitude of the PSC. However, the simultaneous application of glycine (1 μM) and GLYT1 antagonist (100 nM) to the bath induced an enhancement of the amplitude of the PSC. Each trace is the average of five PSCs (V_h = −60 mV). (B) The histogram illustrates the percentage of change of the amplitude of the PSC induced by glycine and/or GLYT1 antagonist compared with control. Glycine (1 μM) did not change the amplitude of the PSC compared with control. GLYT1 antagonist (100 nM) significantly enhanced the amplitude of the PSC. GLYT1 antagonist (100 nM) and glycine (1 μM) enhanced the amplitude of the PSC to a significantly greater extent. The measurement of the amplitude of the PSC was done 4 msec after the beginning of the PSC.