TABLE 2.
Comparison of Median Plasma and CSF Chemokine Concentrations in Survivors and Nonsurvivors by HIV Infection Status
| Parameters | Survivors (n = 70) Median (IQR) |
Nonsurvivors (n = 25) Median (IQR) |
P | |
|---|---|---|---|---|
| HIV infected (n = 59) | Number | 42 | 17 | |
| Plasma CXCL8 (pg/mL) | 49.04 (22.60–246.31) | 159.28 (53.77–1506.73) | 0.03 | |
| Plasma CCL2 (pg/mL) | 43.90 (25.01–276.51) | 536.75 (53.25–1495.05) | 0.002* | |
| Plasma CCL4 (pg/mL) | 248.57 (103.55–708.52) | 626.01 (265.01–1026.31) | NS | |
| Plasma CCL5 (pg/mL) | 38885.40 (20,690.53–79,817.93) | 11790.00 (6609.53–22,541.85) | <0.0005* | |
| CSF CXCL8 (pg/mL) | 92745.58 (26,687.67–133,438.10) | 105125.90 (50,059.85–127,617.80) | NS | |
| CSF CCL2 (pg/mL) | 44374.22 (7296.23–102,695.78) | 145664.05 (45,726.42–216,549.83) | NS | |
| CSF CCL4 (pg/mL) | 24658.24 (8378.61–47,334.08) | 33549.73 (12,002.73–50,717.90) | NS | |
| CSF CCL5 (pg/mL) | 159.20 (44.35–437.55) | 211.50 (111.00–861.30) | NS | |
| HIV uninfected (n = 36) | Number | 28 | 8 | |
| Plasma CXCL8 (pg/mL) | 29.34 (16.84–62.82) | 52.03 (14.72–212.87) | NS | |
| Plasma CCL2 (pg/mL) | 48.59 (15.69–109.25) | 80.95 (19.08–252.44) | NS | |
| Plasma CCL4 (pg/mL) | 171.46 (105.81–343.18) | 270.63 (184.19–311.46) | NS | |
| Plasma CCL5 (pg/mL) | 14543.10 (8333.93–46,072.90) | 24918.85 (6261.26–57,404.50) | NS | |
| CSF CXCL8 (pg/mL) | 35317.24 (17,926.18–89,573.15) | 12765.11 (3583.31–54,666.39) | NS | |
| CSF CCL2 (pg/mL) | 39623.11 (1652.77–65,630.45) | 24853.41 (183.15–65,754.35) | NS | |
| CSF CCL4 (pg/mL) | 10025.39 (5539.22–31,908.47) | 4910.69 (1096.53–9437.13) | NS | |
| CSF CCL5 (pg/mL) | 58.90 (29.70–177.80) | 211.50 (111.00–861.30) | NS |
Values are median concentrations and IQR.
*
Statistically significant result using Bonferroni correction of multiple testing.
IQR indicates interquartile range; NS, not significant.