Table.
Presence and Quantitation of HHV-6 DNA in Specimens from 6 Children with Transplacental Congenital Infection and from their Mothers.
| Children |
Mothers† |
||||
|---|---|---|---|---|---|
| Cord Blood | Peripheral Blood | Saliva | Urine | Hair | |
| No. of Samples | 6 | 5 | 19 | 18 | 6 |
| With HHV-6 DNA:◆ N(%) | 6 (100) | 2 (40)x | 9 (47)x | 0 | 6 (100) |
| Variant: N(% of DNA pos.) | |||||
| HHV-6 A | 3 (50) | 0 | 0 | – | 3 (50) |
| HHV-6 B | 3 (50) | 2 (100) | 8 (89) | – | 3 (50) |
| HHV-6 A and B | 0 | 0 | 1 (11) | - | 0 |
| HHV-6 DNA Load (gec*log10/μg DNA) | |||||
| mean | 3.62 | 3.14 | 4.85 | 0 | 5.64 |
| (range) | (2.35-4.18) | (2.58-3.38) | (3.83-5.48) | – | (5.30-5.86) |
| HHV-6 Antibody | |||||
| with titer >3.32log2 N(%) | 6 (100) | 4 (80) | – | – | – |
| log2 titer: mean | 7.49 | 7.82 | – | – | – |
| (range) | (5.32-9.32) | (5.32-9.32) | – | – | – |
†
Hair follicle samples from all children and their fathers were negative for HHV-6 DNA
◆
HHV-6 mRNA was not detected in any of the blood samples with HHV-6 DNA
x
The HHV-6 DNA positive bloods were obtained at 6 and 12 months of age and the positive saliva samples from 2 to 25 months of age
*
genomic equivalent copies per μg cellular DNA