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. Author manuscript; available in PMC: 2010 Jan 26.
Published in final edited form as: Neuropsychopharmacology. 2006 Jun 21;32(3):710–718. doi: 10.1038/sj.npp.1301129

Figure 1.

Figure 1

Effect of mecamylamine on responses made at the active (top) and the inactive (below) levers during the reinstatement tests for nicotine-seeking behavior. After 30 daily 1-h nicotine self-administration/conditioning training sessions, nicotine-maintained responses were extinguished by saline substitution for nicotine and withholding presentation of the visual cue. Thirty minutes before behavioral tests, rats received s.c. administration of mecamylamine. In the reinstatement test sessions, responses at the active lever resulted in contingent presentation of the cue (1 s lever light on followed by 20 s house light off) without delivery of nicotine infusion (saline substitution), whereas responding at the inactive lever had no consequence. For comparison, extinction responses (averaged across the last three sessions) without mecamylamine pretreatment were provided. The number of responses was presented as mean±SEM in each group (n=8). *p<0.05; **p<0.01 different from vehicle.