Table 2.

Clinical chemistry values for vehicle-treated animals

Clinical Chemistry Parameter	Units	Median	Standard Deviation
Alanine Aminotransferase (ALT)	U/L	58	48
Aspartate Aminotransferase (AST)	U/L	103	101
Lactate Dehydrogenase (LDH)	U/L	529	533
Sorbitol Dehydrogenase (SDH)	U/L	3.1	2.8
Alkaline Phosphatase (ALP)	U/L	318	65
Total Bile Acids (TBA)	μmol/L	11.6	10.4
Cholesterol	mg/dL	52	14
Triglycerides	mg/dL	193	61
Total Protein	g/dL	6.4	0.8
Albumin	g/dL	2.9	0.5
Creatinine	mg/dL	0.3	0.1
Blood Urea Nitrogen (BUN)	mg/dL	18	3

Clinical chemistry measurements were obtained from male Fischer rats 6, 24 and 48 hours after a single dose of vehicle. The vehicle was either corn oil or phosphate buffered saline, pH 7.4. Medians and standard deviations were calculated for each clinical chemistry analytes based on all vehicle treated animals at all time points (n = 103). These values were log transformed and then used as the baseline values for the Z-score transformation. All rats were between 12-14 weeks in age and fasted for 12-18 hours prior to dosing.