Table 1.

Insulin glargine dose titration algorithm and monitoring

Starting dose: 10 IU/day
Titration monitoring	Direct investigator contact. Fasting BG and insulin dose submitted to coordinating center by electronic data capture. Additional weekly calls to adjust insulin dose if A1C >7%
Insulin dose titration
algorithm	If self-monitored fasting BG for 2 consecutive days with no severe hypoglycemia:
	>8.9 mmol/l (>160 mg/dl)	Add 8 IU/day
	>7.8 to ≤8.9 mmol/l (>140 to ≤160 mg/dl)	Add 6 IU/day
	>6.7 to ≤7.8 mmol/l (>120 to ≤140 mg/dl)	Add 4 IU/day
	>5.5 to ≤6.7 mmol/l (>100 to ≤120 mg/dl)	Add 2 IU/day
	5.5 mmol/l (≤100 mg/dl)	No further titration