Table 1. Galectin–glycoprotein lattices that regulate cell functions.
Shown are galectin receptor glycoproteins that have been proposed to participate in lattice formation. This does not constitute a comprehensive list of galectin-binding glycoproteins. DPPIV, dipeptidyl peptidase IV; gp114, glycoprotein 114; MUC1, mucin 1.
Galectin | Cell types affected | Glycoprotein receptors | Functions | References |
---|---|---|---|---|
1 | T-cells, thymocytes | CD3/TCR, CD7, CD43, CD45 | Apoptosis, regulate antigen response | [23–29] |
3 | MDCK (renal epithelia), intestinal enterocytes, T-cells, carcinoma cells | MUC1, LPH, p75, gp114, DPPIV, TCR, EGFR | Stabilize apically targeted vesicles, regulate response to antigen, inhibit growth factor receptor endocytosis | [4,11,19,20,35–38,44] |
4 | Intestinal cell microvilli, HT-29 5M12 (enterocyte-like cells) | Alkaline phosphatase, aminopeptidase N | Lipid raft stabilization, lipid raft-dependent apical targeting | [15,21] |
9 | Osteoblasts, pancreatic β-cells | Glut2 | Lipid raft stabilization, inhibit Glut2 endocytosis | [16,46] |