Table 2.

HR HPV-ISH and p16 Status by Histologic Type, Fisher’s exact test

Histologic Type	K SCC (25)	NK SCC (42)	Hybrid SCC (22)	Total (89)
HR HPV-ISH (%)	2 (8%)	29 (69%)	10 (45.5%)	41 (46.1%)
P value	–	<0.001	0.003
p16 IHC (%)	9 (36%)	42 (100%)	18 (81.8%)	69 (77.5%)
P value	–	<0.001	0.002

K SCC Keratinizing squamous cell carcinoma, NK SCC nonkeratinizing squamous cell carcinoma, Hybrid SCC hybrid squamous cell carcinoma, HR HPV-ISH high-risk human papilloma virus—in situ hybridization, IHC immunohistochemistry