Fig. 2.

Pharmacokinetics of paclitaxel in Cremophor- or liposome-based formulations in mice. a Schematic of the pharmacokinetic model developed to fit data for the Cre-pac and L-pac formulations simultaneously. To accommodate the delayed release of drug from the liposome vehicle and clearance of the carrier by the RES before drug release, an additional compartment (A ₁) was added. It was not necessary to include a drug release term for Cre-pac to obtain satisfactory model fits (RESULTS). b Plasma concentration profiles of Cre-pac and c L-pac formulations administered i.v. to mice. Symbols represent the data points digitized from the original publications (16,24,25). Lines represent the simultaneous fit of the PK model to data for both formulations