Table III.

Pharmacokinetic Parameters of Paclitaxel

Parameters
	Estimate	CV%
Vmax (µg kg−1 h−1)	3,044	14.80
k 12 (1/h)	7.36	12.59
k 21 (1/h)	0.72	13.37
V c (mL/kg)	139.7	26.31
K m (µg/mL)	1.08	31.28
k 10 (1/h)	N/A	N/A
k rel (1/h)	7.17	39.38
k deg (1/h)	7.71	32.23
σ 1 b	0	–a
σ 2 b	0.946	12.2

N/A not applicable

^aFixed value

^bVariance model defined by Eq. 17a,b