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Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN. In unstimulated cells, Keap 1 sequesters Nrf2 and bridges it to Cul-3-dependent ubiquitinase for ubiquitination. The ubiquitinated Nrf2 is then targeted for proteosomal degradation. Both PEITC and SFN can activate Nrf2, although through different mechanisms. PEITC activates Nrf2 through activation of MAPK pathway while SFN modifies thiol group of Keap1 and releases Nrf2 from Keap1 binding
