Table 1.
Clinical Correlation of YAP Expression in HCC
| Clinicopathologic Features | Total No. of Patients, N=177 | No. of Patients | P | |
|---|---|---|---|---|
| YAP Positive | YAP Negative | |||
| Age (mean ± SD), y | 53.9 ± 12.2 | 52.8 ± 12.7 | 55.8 ± 11.2 | .111 |
| Sex | ||||
| Men | 143 | 90 | 53 | |
| Women | 34 | 20 | 14 | .657 |
| Hepatitis | ||||
| Negative | 62 | 41 | 21 | |
| HBV/HCV | 115 | 69 | 46 | .516 |
| No. of tumor nodules | ||||
| 1 | 136 | 86 | 50 | |
| ≥2 | 41 | 24 | 17 | .587 |
| Tumor size (mean±SD), cm* | 7.3 ± 4.6 | 6.9 ± 4.4 | 8.0 ± 4.8 | .142 |
| Serum AFP level, ng/mL | ||||
| ≤400 | 107 | 53 | 54 | |
| >400 | 70 | 57 | 13 | <.001† |
| Venous infiltration‡ | ||||
| Absent | 85 | 50 | 35 | |
| Present | 90 | 59 | 31 | .358 |
| Cellular differentiation§ | ||||
| Well differentiated (1-2) | 33 | 13 | 20 | |
| Moderately differentiated (3) | 89 | 57 | 32 | |
| Poorly differentiated (4) | 30 | 21 | 9 | .021† |
| Adjacent nontumor liver status | ||||
| Noncirrhotic | 18 | 8 | 10 | |
| Chronic hepatitis | 58 | 36 | 22 | |
| Cirrhotic | 101 | 66 | 35 | .242 |
| AJCC tumor stage | ||||
| I | 71 | 42 | 29 | |
| II | 54 | 34 | 20 | |
| III | 52 | 34 | 18 | .772 |
YAP indicates Yes-associated protein; HCC, hepatocellular carcinoma; SD, standard deviation; HBV, hepatitis B virus; HCV, hepatitis C virus; AFP, α-fetoprotein; AJCC, American Joint Commission on Cancer.
*
Tumor size was measured by the length of the largest tumor nodule.
†
Statistically significant.
‡
Venous infiltration was defined based findings on final pathologic analysis (microscopic and major).
§
Scoring was based on Edmonson grade. Partial data are not available, and statistics were based on available data.