Table 4.
Cox Regression Analysis of HCC-Specific Postoperative Disease-Free Survival
| All Patients (n=164)* | Patients Without Venous Infiltration (n=81), Multivariate Analysis | ||||||
|---|---|---|---|---|---|---|---|
| Univariate Analysis,†P | Multivariate Analysis | ||||||
| P | Hazard Ratio | 95% CI | P | Hazards Ratio | 95% CI | ||
| Age | .421 | .099 | 1.015 | 0.997-1.034 | .003‡ | 1.055 | 1.019-1.092 |
| Sex | .832 | .236 | 0.728 | 0.431-1.230 | .123 | 0.492 | 0.200-1.211 |
| Hepatitis | .007 | .051 | 0.671 | 0.450-1.001 | .865 | 1.067 | 0.504-2.260 |
| No. of tumor nodules | .009 | .019‡ | 2.040 | 1.126-3.697 | .940 | 1.064 | 0.209-5.421 |
| Tumor size | .001 | .004‡ | 1.070 | 1.021-1.120 | .015‡ | 1.104 | 1.019-1.196 |
| Venous infiltration | <.001 | .041‡ | 2.049 | 1.029-4.080 | NA | NA | NA |
| AJCC tumor stage | |||||||
| I | 1 | 1 | |||||
| II | .011 | .505 | 0.762 | 0.343-1.694 | .366 | 2.332 | 0.372-14.636 |
| III | <.001 | .553 | 0.773 | 0.328-1.820 | .998 | 1.002 | 0.204-4.908 |
| Serum AFP level | .046 | .474 | 1.163 | 0.769-1.759 | .974 | 1.013 | 0.460-2.234 |
| YAP expression in tumor | .073 | .020‡ | 1.653 | 1.081-2.528 | .001‡ | 3.547 | 1.644-7.653 |
HCC indicates hepatocellular carcinoma; 95% CI, 95% confidence interval; NA, not applicable; AJCC, American Joint Committee on Cancer; AFP, α-fetoprotein; YAP, Yes-associated protein.
*
Venous infiltration data were not determined in 2 patients.
†
Univariate analysis was performed using Cox regression.
‡
Statistically significant.