Figure 1.

Auditory-evoked brainstem responses in TRα1- and TRβ-deficient mice. Columns indicate mean ABR thresholds ± SEM in dB sound pressure level for click, 8-, 16-, and 32-kHz frequency stimuli. Thresholds of TRα1^−/− mice were not significantly different from wt mice, whereas TRβ^−/− mice have significantly elevated thresholds over TRβ^+/+ or TRβ^−/+ mice (∗∗, P < 0.01; ref. 15). Numbers of mice per group: n = 4, TRβ^−/+; n = 9, TRβ^−/−; n = 6, TRα1^+/+; n = 8, TRα1^−/−. TRβ^−/− and TRα1^−/− mice were compared with control mice (TRβ^−/+ and TRα1^+/+, respectively) of the corresponding genetic backgrounds (see Materials and Methods).