Figure 3.

Theoretical power of co-classifying rare risk haplotypes for the sibpair and unrelated-case designs. Three modes of inheritance were considered: multiplicative f₂ = λ f₀, $f_1=\sqrt{\lambda }{f}_0$; dominant f₂ = f₁ =λ f₀ and recessive f₂ = λ f₀, f₁ = f₀. Haplotype frequencies in the population are known. 300 affected sibpairs and 600 unrelated cases were used. The cumulative risk haplotype frequency is 10%. Left panel: individual risk haplotype frequency is 0.5%. Right panel: individual risk haplotype frequency is 1.0%.