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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Genet Epidemiol. 2010 Feb;34(2):171–187. doi: 10.1002/gepi.20449

Figure 4.

Figure 4

Power comparison for the affected sibpair design, unrelated-case design and single marker analysis. Power was calculated at the 10-6 significance level based on 1,000 replications. Haplotype phases are known. Haplotype frequencies were based on the ACE gene in an African population. There are 8 true risk haplotypes and the corresponding haplotype frequencies are between 1.0%-1.5% with cumulative risk haplotype frequency 10%. The lines represent the power of the three different modes of inheritance for different sample sizes used at stage 1, with the total sample size always kept the same. Single SNP association analysis was conducted on 2000 cases and 3000 controls but corrected for multiple comparisons[Nyholt 2004]. Linkage score was averaged from 1,000 replications using the mean test score of alleles shared identical by descent.

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