Table 2.
Genes showing association evidence in the WTCCC HT and CAD samples in the stage 2 association test.
| Genes | Chromosome | Cumulative risk haplotype frequency |
Fisher exact test P-value | Are all SNPs good? | |
|---|---|---|---|---|---|
| Cases | Controls | ||||
| Hypertension | |||||
| TLR4 | 9q32-33 | 0.056 | 0.0188 | 1.76×10-16 | No |
| ZFAT1 | 8q23-24 | 0.0384 | 0.0116 | 4.92×10-13 | Yes |
| CAD | |||||
| MEF2B | 19p12 | 0.0372 | 0.0095 | 1.04×10-15 | No |
| EIF4H | 7q11.23 | 0.0120 | 0.0005 | 1.15×10-11 | Yes |
| CDKN2B | 9p21 | 0.2832 | 0.2247 | 8.75×10-9 | No |
| HFE2 | 1q21 | 0.0065 | 0.0003 | 8.37×10-7 | Yes |
| ZBTB43 | 9q33-34 | 0.0274 | 0.0119 | 1.29×10-6 | Yes |
| CDR2L | 17q25.1 | 0.0052 | 0.0 | 1.57×10-6 | No |