Table 3.
Risk haplotypes and their corresponding frequencies in cases and controls for WTCCC HT and CAD data
| Gene | Chr | Start SNP | End SNP | Haplotype | Freq in cases | Freq in controls | Fisher’s exact test p-value |
|---|---|---|---|---|---|---|---|
|
HT | |||||||
| ZFAT1 | 8 | rs6988616 | rs11778878 | 001000101111100101111101100100 | 0.001281 | 0.000173 | 4.21×10-2 |
| 001100100110110001000001101100 | 0.002049 | 0.000345 | 1.28×10-2 | ||||
| 001110101011100001010111111010 | 0.011527 | 0 | 1.40×10-18 | ||||
| 100100000101110011000001100100 | 0.004611 | 0.001553 | 4.94×10-3 | ||||
| 111010101011100001010111111010 | 0.012295 | 0 | 8.95×10-20 | ||||
|
CAD | |||||||
| CDKN2B | 9 | rs3217986 | rs10965245 | 000000010000000010101111100000 | 0.011942 | 0.005956 | 1.27×10-3 |
| 100000010000000010101111100010 | 0.223780 | 0.189074 | 1.77×10-5 | ||||
| 100000010000000010101111100011 | 0.015576 | 0.007658 | 1.55×10-4 | ||||
| 101001101100111010101111100010 | 0.045691 | 0.037270 | 2.40×10-2 | ||||
| 101111010000000010101111100010 | 0.011423 | 0.007488 | 2.45×10-2 | ||||
| EIF4H | 7 | rs150880 | rs17146094 | 0100 | 0.011942 | 0.000511 | 1.13×10-15 |
| HFE2 | 1 | rs12091564 | rs10218795 | 00 | 0.006490 | 0.000511 | 6.54×10-8 |
| ZBTB43 | 9 | rs10987465 | rs7038622 | 01001101100101 | 0.006750 | 0.000851 | 5.15×10-7 |
| 01001111110001 | 0.003894 | 0.000511 | 1.86×10-4 | ||||
| 01101111110001 | 0.003894 | 0.000340 | 4.90×10-5 | ||||