Fig. 2.

Termination of KA-induced SE by diazepam, 3 h after its onset, reduces neuronal neurodegeneration in the amygdala, piriform cortex, and endopiriform nucleus during epileptogenesis. Nissl-stained (a) and Fluoro-Jade C-stained (b) sections demonstrating the medial (Me), basolateral (BLA) nuclei of the amygdala, the piriform cortex (Pir), and endopiriform nucleus (En). The Fluoro-Jade C-stained sections are shown at higher magnification in c. The number of irreversibly degenerating cells in the rats that were administered diazepam (KA +DZP group), 3 h after the onset of SE, was significantly lower than the number of degenerating cells in the group that was not treated with diazepam (KA group). Staining in this example was performed 7 days after SE. Scale bar 300 μm