Fig. 3.

Quantitative and qualitative analysis of Fluoro-Jade C staining reveal that termination of KA-induced SE by diazepam, 3 h after its onset, reduces neuronal degeneration during epileptogenesis in the amygdala, piriform cortex, and endopiriform nucleus, but not in the hippocampus. a Comparison of the number of Fluoro-Jade C positive stained cells per mm² in the amygdala, hippocampus, piriform cortex and endopiriform nucleus of rats in which SE induced by kainic acid was not terminated (KA group; n = 4 rats) and rats in which SE was terminated after 3 h with diazepam (KA +DZP group; n = 5 rats). b Qualitative assessment of the extent of neurodegeneration produced similar relationships between the KA group and the KA +DZP group, as the quantitative evaluation; scale: 0 no damage, 1 minimal damage (0−10%), 2 mild damage (10−25%), 3 moderate damage (25−45%), 4 severe damage ([45%). Values are mean ± SEM, *P < 0.05, **P < 0.005; ***P < 0.001