Table 1.
Changes in scores on the SF-36 questionnaires in HV according to different test drugs before and after endoscopic procedures
| Test drug day |
Physical score |
P |
Mental score |
P |
Total score |
P | |||
| 0 | 14 | 0 | 14 | 0 | 14 | ||||
| Placebo | 88.7 ± 5.9 | 88.2 ± 4.1 | NS | 85.7 ± 8.5 | 86.0 ± 7.8 | NS | 89.9 ± 6.2 | 89.8 ± 4.8 | NS |
| Esomeprazole | 85.7 ± 7.7 | 84.1 ± 6.0 | NS | 83.3 ± 6.2 | 83.0 ± 6.0 | NS | 86.2 ± 7.2 | 87.4 ± 4.8 | NS |
| Clopidogrel | 86.6 ± 6.5 | 85.5 ± 6.7 | NS | 84.0 ± 7.3 | 83.8 ± 8.2 | NS | 88.1 ± 6.1 | 87.0 ± 6.3 | NS |
| Prednisolone | 85.1 ± 5.2 | 82.2 ± 9.6 | NS | 81.9 ± 7.0 | 82.6 ± 6.4 | NS | 87.0 ± 5.4 | 85.7 ± 6.7 | NS |
| Rofecoxib | 86.2 ± 8.2 | 86.4 ± 3.1 | NS | 85.0 ± 6.2 | 84.5 ± 4.7 | NS | 88.3 ± 6.5 | 88.4 ± 3.1 | NS |
| Total Scores | 86.4 ± 1.3 | 85.4 ± 2.0 | NS | 83.5 ± 1.3 | 84.2 ± 1.2 | NS | 87.8 ± 1.2 | 87.8 ± 1.5 | NS |
Test drugs were given for one week alone and for an additional week in combination with low-dose aspirin. Four-week washout periods were performed between the different drug phases. Results expressed in mean ± SD, paired t-test: P > 0.05 listed as NS. HV: Healthy volunteers.