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. 2009 Nov 4;42(1):47–60. doi: 10.3858/emm.2010.42.1.005

Figure 5.

Figure 5

Salicylic acid (SA) does not attenuate the anti-inflammatory properties of theophylline. Evaluation (n = 5 each group) was performed after allergen challenge. PBS, mice challenged with PBS; OVA, mice sensitized with ovalbumin + lipopolysaccharide and then challenged with ovalbumin; *P < 0.05 compared to the PBS_sham group; **P < 0.05 compared to the other groups. (A) BAL cellularity 48 h after the final allergen challenge. (B) Lung inflammatory scores based on histology 48 h after the final allergen challenge (left panel) and representative lung histological findings (right panel) obtained 48 h after the final allergen challenge (a: PBS; b: OVA_SA; c: OVA_theo; d: OVA_theo/SA, H&E stain, 200×). (C) Number of IFN-µ-producing CD4+ T-cells in lung tissues 6 h after allergen challenge on day 21. (D) IL-12 in BAL fluids collected 48 h after the final allergen challenge.